عنوان المقالة:ابيشتين بار فيروس و ليمفوما خلايا بي. هل هناك أي علاقة؟ Epstein–Barr virus infection in B-cell Non-Hodgkin’s Lymphomas of the Oral and Maxillofacial Region: Is there any evidence?
ليلى مصطفى عبدالرحيم،بيه سوت تشينغ و توماس جورج كلاركال
المؤلفون بالإنجليزي
Laila Mustafa ABDELRAHIM, Suat-Cheng PEH* and Thomas George KALLARAKKAL
الملخص الانجليزي
Introduction: Epstein–Barr virus (EBV) might be an aetiological agent involved in the pathogenesis
of certain Non-Hodgkin’s Lymphomas (NHLs). EBV infection has been diagnosed by serologic
testing within the tumour biopsies of patients with NHL. However, the association between EBV
and NHL is inconsistent with a preference for certain anatomic sites, histologic subtypes and
immunosuppressed patients. The objective of this study was to characterise the B-cell NHLs of the
oral cavity and maxillofacial region using histological and immunophenotypical techniques and to
determine its association with EBV infection. Materials and Methods: This was a descriptive cross-
sectional study that included 14 cases of B-cell NHLs of the oral cavity and maxillofacial region.
The haematopoietic and lymphoid tissue tumours classification of WHO was used to categorize the
cases. In-situ hybridisation for EBV–encoded RNA was performed to confirm the EBV infection.
Results: The average age of the patients included in the study was found to be 48.8 ± 23 years
with a higher female to male ratio (1.3:1). Our study suggested that diffuse large B-cell lymphomas
(DLBCLs) and Burkitt’s lymphomas (BLs) constitute the predominant subtypes of lymphomas
affecting the oral cavity and maxillofacial regions. Conclusion: The findings from our study support
the view that at least a relatively smaller proportion of B-cell NHLs that occur in the oral cavity
and maxillofacial region do not have a pathogenic association with EBV.cavity