عنوان المقالة:Association of Estrogen-metabolizing Gene polymorphisms CYP 1A1 MspI (rs 4646903) and CYP C17 (rs 11191548) with breast cancer in Iraqi patients
د. حامد جدوع عباس | Dr. hamed Jaddoa Abbas | 13766
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- Abdul Hussein A. Algenabi, Hamed Jadoa Abbas, Talib Hussein Kamona
- الملخص العربي
- Abstract: Estrogen has been proposed to trigger breast cancer development. Increase or prolong exposure to estrogen can damage the DNA molecule and increase the genomic instability process in breast tissue. To examine this hypothesis, case-control study was conducted to determine whether polymorphisms of the genes responsible for estrogen biosynthesis (CYP17) and hydroxylation (CYP1A1) are associated with an elevated risk for breast cancer in Iraqi women. Three hundred breast cancer women and 170 healthy controls were recruited. Polymerase chain reaction– restriction fragment length polymorphism (PCR- RFLP) assays were used to determine the genotypes of estrogenmetabolizing genes. The homozygous mutant genotypes (vtvt) of CYP 1A1 in codominant was significantly increased the risk of breast cancer to 3.34 folds with respect to those of the wild type (wtwt). The homozygous mutant genotype (A2A2) of CYP 17 in codominant was significantly increased the risk of breast cancer 3.86 folds with respect to those of the wild type (A1A1). The findings of this study revealed that CYP1A1 and CYP17 genes polymorphisms were associated with breast cancer in Iraqi women.
- تاريخ النشر
- 30/11/2012
- الناشر
- Journal of Chemical, Biological and Physical Sciences
- رابط الملف
- تحميل (475 مرات التحميل)
- الكلمات المفتاحية
- CYP1A1, CYP17, Gene polymorphisms, Breast Cancer.