عنوان المقالة:تقييم مستوى Tumor Necrosis factor Alfa في مصل مرضى بعض سرطانات الجهاز الهضمي في العراق INCREASING SERUM LEVEL OF TUMOR NECROSIS FACTOR ALPHA IN SOME GASTROINTESTINAL CANCERS IN IRAQI PATIENTS
احمد رشدي عبد الله ، شيماء يوسف عبد الفتاح، علي حيدر محمد علي ، براء عبد الهادي عبد الحميد
المؤلفون بالإنجليزي
Ahmed R. Abdullah* Shaimaa Y. Abdulfattah Ali H.M. Ali Bara A. Abdulhameed
الملخص العربي
البحث يصبو لمعرفة امكانية ان يكون TNF alfa كدالة حيوية
الملخص الانجليزي
ABSTRACT: Gastrointestinal cancers (GITs) are a worldwide problem particularly in the highly developed countries. In Iraq , gastric cancer(GC) is the 9th most common cancer while colorectal cancers (CRC) is considered as the 7 th most common cancer among all cancer patients in both males and females. The Objective of this study was to estimate the serum level of Tumor Necrosis factor alpha (TNF-Į) in some Iraqi colorectal and gastric cancer patients. In this study, 54 serum samples were collected starting from the 1st of January till the mid of March 2011 to investigate the TNF-Į serum level by using ELISA technique. Thirty eight samples were gastric (H. pylori +ve) and colorectal cancer patients (GC=17, CRC=21) and 16 samples considered as a healthy control group. The results showed that TNF-Į serum levels of both GIT tumors were increased significantly (P<0.05) comparing to the healthy control group. In conclusion, as previous literature showed a correlation between the increase of TNF-Į production and the genetic expression of the TNF-Į alleles, the present data recommend further analysis of TNF-Į alleles for Iraqi GC patients. This could be useful to detect the risk of failure of first-line chemotherapy and overall survival of Iraqi GC patients. Furthermore, since high serum levels of TNF-Į in CRC patients was shown previously to correlate with worse prognosis of the tumors, the present data could point out to use this elevation as a biomarker for tumor prognosis in Iraqi CRC patients.
KEY
احمد رشدي عبد الله | Dr Ahmed Rushdi Abdullah | 2636