The age of antibiotic prophylaxis began shortly after world War II with the introduction of penicillin to the general population and received significant impetus from the introduction of the first American Heart Association (AHA) recommendations for the prevention of bacterial endocarditis (BE) in 1955. Since that time, considerable effort has been expended to prove its efficacy, develop the appropriate drugs and dosages and determine its clinical indications. It was not until the mid-1980s that any attention was directed towards its potential adverse effects, particularly regarding penicillin allergy. Currently, one of the major concerns with antibiotic prophylaxis is its use in large populations and how this might contribute to the global problems with microbial resistance to antibiotics( levy,2002)
أ.د. أمل طالب عطيه السعدي | Prof. Dr. Amal Talib Atiyah Al Sa'ady | 6999