عنوان المقالة:التغيرات النسيجية والفسيولوجية في أنسجة الكلى التي يسببها حمض الإيثانويك في الجرذان البيضاء Histological and physiological changes in kidney tissues induced by ethanoic acid in albino rats.
د. عيدة مفتاح عبدالكريم الشيلابي | Dr. Eda M. A. Alshailabi | 5680
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- عيدة مفتاح عبدالكريم الشيلابي وسالمة فرج مجيد وأحمد سعيد احميدة
- المؤلفون بالإنجليزي
- Eda M. A. Alshailabi, Salma F. Majeed and Ahmed S. H. Ahmeedah
- الملخص العربي
- لا يوجد
- الملخص الانجليزي
- Ethanoic acid (EA) is a widely used organic acid with corrosive properties. A small amount of its concentration may cause serious poisoning with a fatal outcome. This study aimed to investigate the histological and physiological changes on kidney tissues induced by EA in female albino rats. Thirty female rats were used, they were divided into three groups, one group serves as control group and the other groups were administered the EA as follows: Treated group (1); animals received EA (1 ml/ kg/ day) with concentration of 5 % and treated group (2); animals received EA (1 ml/ kg/ day) with concentration of 10 % orally by gavage for fourteen days. The mean values of creatinine observed in treated animals do not differ significantly from the corresponding values observed in controls. Whereas, the results showed a significant increase in urea levels in rats that received EA-10% as compared to EA-5 % rats and control rats. Histological observations in kidney tissues showed degeneration of renal glomerulus with widening of Bowman’s space, hyalinization of glomerular tuft and tubular basement membrane degeneration in glomerulus, indicating dilated tubule in EA-5% rats. Moreover, the EA-10% groups showed degenerative lesions in glomerulus with lymphocytic infiltration cells, severe dilatation and vascular congestion with clogging of RBCs. In conclusion, ethanoic acid consumption have adverse effects on renal function in rats, hence quantity of ethanoic acid should be discouraged or reduced in making of meals.
- تاريخ النشر
- 30/03/2021
- الناشر
- International Journal of Multidisciplinary Sciences and Advanced Technology
- رقم المجلد
- 1
- رقم العدد
- 1
- ISSN/ISBN
- عدد خاص
- رابط DOI
- لا يوجد
- الصفحات
- 306–312
- رابط الملف
- تحميل (0 مرات التحميل)
- رابط خارجي
- http://www.ijmsat.com
- الكلمات المفتاحية
- Histological, Physiological, Kidney, Ethanoic Acid, Rat.