با ن شاكر الجوده ,نورهان خالد شفيق ,رائد عبد الحميد
المؤلفون بالإنجليزي
Ban Mahmood Shaker Aljoda * ; Noorhan K. Shfeeq**; Raed A . Abdulhameed
الملخص العربي
The study aimed to evaluate Glucagon-Like Peptide-1 levels in Polycystic ovary
syndrome(PCOS) infertile female with Diabetes Mellitus (DM) and compare the
results with control group , also , to find the correlation for GLP-1 with Luteinizing
hormone(LH), Follicle stimulating hormone(FSH) and LH/FSH ratio that may be
used in prediction atherosclerosis in these patients. The study included nineteen
women with age ranged(30-40) years and BMI ranged between (30-35) Kg/m2
.
Subjects were divided into two groups: group(1) consist of (45)females as a healthy
control and group(2) consist of (45) infertile females with PCOS and DM as
complication . Fasting serum glucose was determined by using commercial kits
(Biolabo SA-France); LH , FSH , prolactin were determined by ELISA, fasting serum
insulin was determined by using ELISA kit(DRG-Germany).Insulin-resistance(IR)
calculated by (HOMA-IR) . FSH , LH , LH/FSH ratio and prolactin levels for all
studied groups were measured . A highly significant elevation in prolactin, LH and
LH/FSH ratio was found when G1 comparing with G2 . While significant reduction
seen in FSH levels in G2 comparing to G1 . A high significant elevation in Fasting
blood glucose , % HbA1C levels in patients group when comparing to healthy
control . Results revealed a highly significant elevation in insulin,HOMA-IR and
glucagon, while there are a significant reduction in GLP-1levels. There is significant
positive correlation was found in GLP-1 levels with (FSH) in G1 ,while a significant
negative correlation was observed in levels of GLP-1 and (FSH) inG2. A significant
negative correlation was found in GLP-1 levels and (LH) in G1 ,while a positive correlation was found in GLP-1 levels with (LH) in G2 . Results illustrated
significant negative correlation was seen in levels of GLP-1 with LH/FSH ratio in
G1,while there are a significant positive correlation in GLP-1 levels with LH/FSH
ratio in G2 . The conclusion could be drown from this study that GLP-1 has a
correlation with LH , FSH which may be considered as a marker in PCOS patients
with DM that prone to atherosclerosis significant
نورهان خالد شفيق | Noorhan Khaled | 4075