عنوان المقالة: The impact of zinc oxide nanoparticles (ZnO-NPs) on the kidney structure of male albino mice
جنان عدنان عبد اللطيف البيروتي | Genan Adnan Abdul-Bairuty | 5396
نوع النشر
مجلة علمية
المؤلفون بالعربي
باسم سلطان الزرجاوي وجنان عدنان عبد اللطيف البيروتي
المؤلفون بالإنجليزي
BSO Al-Al Zerjawe, GAA Al-Bairuty
الملخص الانجليزي
According to the distinctive physical and chemical properties, zinc oxide nanoparticles (ZnO-NPs) are widely used in a multitude of applications such as medical diagnosis, preparation of pharmaceutical products anti-sunshine, deliver drugs to target parts in the body and cosmetics. The objective of this study was to investigate the impact of ZnO-NPs on the kidney structure of male albino mice by using intra-peritoneal injection. Animals were injected with 0.1 ml of 150 mg kg-1 of ZnO-NPs (25-45 nm size) for a period of 7 and 14 days. The results showed a decrease in the average body weights of animals after 14 days of injection with ZnO-NPs when compared with control group (p ≤ 0.05), while, the period of seven days did not caused any alteration in the mice average body weights. A decrease was recorded in the diameter of renal glomerular after 14 days of injection with 150 mg/kg ZnO-NPs, and an increase was recorded in the space of Bowmann’s capsule after 7 and 14 days of injection with 150 mg kg-1 ZnO-NPs compared with the control animals (P ≤ 0.05). The diameter of proximal and distal tubules showed statistically significant increase (P ≤ 0.05) after injection with 150 mg kg-1 ZnO-NPs for 7 and 14 days compared with control groups. The histological examination revealed injuries in the kidney structure after 7 and 14 days of exposure to ZnO-NPs which were involved accumulation of inflammatory cells close to the blood vessel, sloughing and degeneration of lining epithelium in renal tubule, necrosis, foci of nucleus hypertrophy, congestion of blood vessels, lose and atrophy of glomerulus, intratubular calcium deposition and shrinkage of glomerulus. However, the histopathological changes in the kidney after 14 days of injection were more severe than at day 7. We conclude that ZnO-NPs could have serious kidney structure and functional toxicological impacts.
تاريخ النشر
25/03/2020
الناشر
AIP Conference Proceedings
رقم المجلد
2213
رقم العدد
1
رابط DOI
10.1063/5.0000148
الصفحات
020046
رابط الملف
تحميل (78 مرات التحميل)
رابط خارجي
https://www.researchgate.net/publication/340177658_The_impact_of_zinc_oxide_nanoparticles_ZnO-NPs_on_the_kidney_structure_of_male_albino_mice
الكلمات المفتاحية
Kidney, Zinc oxide Nanoparticles, Male albino mice, Histopathological
رجوع