This study was conducted to determine the weight changes in their bodies and some organs system of albino mice that orally administrated with silver nanoparticles (Ag-NPs). Use 20 mice were divided into two groups: the first group as a control (5 animals) and the second group administrated with 200 mg/kg BW of Ag-NPs for 5, 10, and 15 days. Each period involved 5 animals. The animals weighted before and after the end of the treatment period and dissected to collect the organs (liver, spleen, kidney, gastrointestinal tract (GIT), heart and seminal vesicle) for weighting. Results indicated to obtain significant decrease (P<0.05) in the average body weights of animals after the end of each treatment period compared to the period before treatment. The results also showed a significant decrease (P<0.05) in the average coefficient relative weight of the spleen after 5 days of treatment compared to the control group. Whereas, there was a significantly increase (P<0.05) in the average coefficient relative weight of the kidneys, GIT, lung and heart after 10 days of treatment compared with the control groups. So, it seems that Ag-NPs have a negative effect on the animals' body weights and the internal organs system. Therefore more studies are necessary to evaluate the effects of this material on the histology structure of these organs.
جنان عدنان عبد اللطيف البيروتي | Genan Adnan Abdul-Bairuty | 5397