عنوان المقالة:تخليق وتوصيف وتقييم النشاط الحيوي للعديد من مجمعات أيون-بيوفلافونويد المعدنية الانتقالية ثنائية التكافؤ Synthesis, Characterization, and Bioactivity Evaluation of Several Divalent Transition Metal Ion-Bioflavonoid Complexes
Eishah Mohsen , Adel A.M. Saeed,Abdul Rahman A. Bin Yahya,
الملخص الانجليزي
Interest in organic polyphenol compounds increases if these natural compounds are coordinated with transition
metal ions. In this study, four metal complexes were synthesized with flavonoid extracts, and reliable techniques
were used for characterization. These complexes showcase unique coloring, low pH, and conductivity levels, with
X-ray diffraction revealing varying crystallinity among flavonoid extracts and certain complexes. Fourier
transform infrared spectrophotometer exhibits a specific stretching vibration (442–486 cm− 1 ν M− O), indicating
flavonoid metal complex formation formation. UV–visible spectrum of flavonoid extracts displays absorption
bands at 280 and 340 nm, shifting upon metal ion binding to unveil new absorption bands for each complex,
producing three peaks between 260–660 nm. The 1
HNMR results showed that the proton signals in all complexes
shifted to a high field relative to their ligand, possibly due to increased coupling caused by the coordination
effect and thus increased planarity of the flavonoid molecules. These organic metal complexes display heightened
antioxidant, antimicrobial, and anticancer properties compared to extracts, with enhanced cytotoxicity against
THP-1 and Calu-3 cell lines, notably Cu(II) displaying superior cytotoxic effects with IC50 values of 18 and 56
μg/mL for THP-1 and Calu-3 cells respectively.
تاريخ النشر
11/05/2024
الناشر
Elesiver
رقم المجلد
7
رقم العدد
رابط DOI
https://doi.org/10.1016/j.rechem.2024.101535
الكلمات المفتاحية
Metal complexes Characterization Bioflavonoids Activity
د. عادل أحمد محمد سعيد | Dr. Adel Ahmed Mohammed Seaad | 13534