Shatha Ali Shafiq1, Sura Basil Kamal1, Sabaa Taher Mohammed1, Nidaa Mohammed1, and Roua Jamal Abdulkhaliq2.
الملخص الانجليزي
The screening study to search for new natural antiprotozoals, we screened the commercial product seaweed extract of brown
algae Ascophyllum nodosum and tested them in vitro and in vivo against Leishmania donovani parasite the responsible for
one of the major endemic parasitic diseases ,the viability rate after treated with seaweed extract was decreased with increasing
of concentration at 50% was (35.62%,16.51% and 0 ) after (15min, 30min and 1hrs) respectively ,but in concentration 25% the
viability became (50.30%,35.30% and 0) after the same incubation period compared with control treatment and drug treatment
(pentostam) . The histological changes of liver tissue for treating males white mice orally with seaweed extract for three weeks
after injecting with 1×106 cell/ml intraperitonial by Leishmania donovani showed As observed a clear improvement in liver
hyperplasia in kupffer cell , and hydropic degeneration but noticed reduce presence of parasites and approximately mild
reaper occur beside the group of mice treated with drug pentostam , compared with the positive control ( mice inoculated
orally 0. 1ml/day) normal saline . The histological section of liver for infected mice with leishmamial parasites showed
haemorrhage, infiltration of lymphocytes, proliferative for kupffer cell as a result of the presence of parasites.
شذى علي شفيق | Prof.Dr. Shatha Ali Shafiq | 2585