عنوان المقالة: Biochemical and Clinicopathological study of phospholipase D1and Choline Kinase Alpha enzymes in Women with Invasive Ductal Carcinoma of the Breast in Thi- Qar Province- Iraq.
Breast cancer is a complex and multi factorial disease resulting in abnormal cell growth that leads to malignant tumor formation. The present study is designed to determine the levels of {phospholipase D1enzyme (PLD1), choline kinase alpha enzyme (CHKA) } , pineal gland hormones (Serotonin, Melatonin) (ST , MT), Estradiol (E2) , asses the titer of C- reactive protein (CRP), (Adiponectin hormone, Vitamin D3, Calcium) (ADP,Vit.D3,Ca), and (Alkaline phosphtase enzyme) (ALP), in women with invasive ductal carcinoma and healthy individuals. The study includes (160) women who are divided into two groups: (85) women of invasive ductal carcinoma with age range (25―65) year and (75) supposed healthy subjects (control) with age range (25 −65)year. The study aims to shed a light on the possible correlation between phospholipase D1enzyme (PLD1) and each one of the studied parameters. The results show that there is a significant increase in serum concentrations of each (PLD1), (CHKA), (E2) , (CRP), (Ca) and (ALP) in all patients in comparison with control group (P≤0.05). Whereas there is a significant decrease (P≤0.05) in concentrations of serum (ST), (MT), (ADP), and (Vit.D3), in all patients in comparison with (control) group .
م.د. هديل رشيد فرج | Dr.Hadeel Rashid Faraj | 4056