كرم هاشم الملاح ، ناظم احمد حسن ، انتصار منصور عبدالرسول
المؤلفون بالإنجليزي
Karam Hashim Al-Mallah , Nathim Ahmad Hassan , Entissar Mansour Abdul-Rasoul
الملخص الانجليزي
This study was designed to detect the effects of aluminium chloride AlCl3on some pathophysiological features of adult male rats , Eighteen rats were used in this study , devided to 3 groups with 6 animals for each group , These included untreated control and 2 treated groups received AlCl3 at the doses 40 mg / kg of Body weight and 80 mg/kg of Body weight orally and daily for 30 days , the following parameters were recorded , 1st : Body weight (weekly) , 2nd : Central nervous system ( CNS) activity tests (weekly) , 3rd : Hematological examinations at 15 and 30 days of experementaly , 4th : Gross and histopathology for brain , liver , kidneys and heart at the day (30) : the results at ( p≤0.05) showed a significant decrease in body weight mean of 3rd group (80 mg / kg . BW) at 4th week ,a significant decrease in the (CNS) activity associated with time progress in experiment by recording ( moving onset , square crossed and rearing in 3 minutes , negative geotaxis ) tests , there were no significant differences between groups at pack cell volume (PCV) and hemoglobin concentration ( HB) with a significant decrease in total leukocyte count at 2nd group ( 40 mg / kg . BW) . diffrential leukocytic count (DLC) revealed significant increase in lymphocyte at day (30) . Histopathological changes also obsearved manifested by neuronal vaculation and proliferation of microgelial cells in brain , vacular degeneration and lymphocytic infiltrations in hepatic parenchyma with mild portal fibrosis in liver , at kidneys there were cloudy swelling , coagulative necrosis to the renal tubular epithelium , more severlely noticed at 3rd group , No pathological changes were noticed at myocardium and coronary arteries at both treated groups.
كرم هاشم يحيى الملاح | Karam Hashim Yahya Al-Mallah | 2831