عنوان المقالة:مستويات GLP-1, GPCR وعاتقتها مع بهض المتغيرات في المرضى العراقيين الذين يعانون اختلال نسية الدهون في الجسم الغير مصابين بداء السكر GLP-1, GPCR Levels and their Relationshipwith Some Parameters in Non-diabetic Dyslipidaemia in Iraqi Patients
Zeinab Moneb. Al-Rubaei, TamaraAla`a Hussein, and Noorhan Khalid.Shafeeq
الملخص العربي
Abnormalities in the Lipid and lipoprotein levels are common in the general population and are
considered as very important risk- factors for cardiovascular disease .In this context the effect of cholesterol,
which is one of the most clinically relevant lipids is very important. Aim of the present study was to determine
the levels of GLP-1 and GPCR in non- diabetic dyslipidaemic patients and compare the results with the control
group, which may be used as a novel biomarker to predict heart disease in these patients. The study was also
aimed to find the relationship between GLP-1 and GPCR with lipid profile and glucagon in the patient group.
The study involved 90 non-diabetic dyslipidaemia patients, with 90 healthy controls. The subjects were matched
by age (35-50 years) and body mass index (BMI) (28 kg/m2). Blood samples were collected from healthy controls
and dyslipidaemic patients after 12-14 hours of fasting. The study was conducted between January 2015–
September 2015 in the Ibn- Al Naphes hospital in Baghdad province / Iraq .Diabetic patients were exclusion from
this study. BMI were determined for all student groups.FBG, Lipid Profile ,glucagon, GLP-1, GPCR was determined
in the control and patient groups. The results are expressed as mean ± SEM. Student ̓s t-test was used to
compare the significance of the variation between dyslipidaemia and control groups. Results showed nonsignificant
elevations in BMI, FBS, and HbA1c levels in the patient group compared with the control group. There
was a significant elevation in TC, TG, LDL-c, and VLDL-c levels in the patient group compared with the control
group, while a significant decrease was noticed in HDL-c level in the patient group compared with the control
group .There was also a significant elevation in glucagon, while a highly significant elevation in GLP-1 and GPCR
levels in the patient group when compared with the control group. A significant correlation was observed
between GLP-1 with TC, TG, HDL-c, and GPCR in the patient group. There was also a significant correlation
between GPCR with TC, TG and HDL-c in the patient group. From this study, it is concluded that a significant
increase in GLP-1and GPCR levels, in addition to their correlation with TC, TG, HDL-c and glucagon in the patient
group, compared to the control group indicate that these parameters could be used as a novel biomarker to
predict heart disease in these patients in future
تاريخ النشر
30/03/2017
الناشر
Research Journal of Pharmaceutical, Biological and Chemical Sciences
نورهان خالد شفيق | Noorhan Khaled | 3789