عنوان المقالة:دراسة التركيز الكلي للحامض النووي RNA ومستويات نشاط التريبتيز في مرضى قصور القلب Study of Total RNA Circulation and Tryptase Activity Levels in Heart Failure Patients
Nagham Qasim Kadhim , Fawzi Hassan Zayr and Sabah Fadhil Al-Qurashy
الملخص الانجليزي
ABSTRACT
Background: Heart Failure (HF) take place when heart muscle couldn't pump blood as it should. HF is a
clinical disorder that occurs due to structural and functional weakness in the myocardium leading to a weak
ventricle in the blood pump. Methods: Serum Tryptase and Total RNA Blood were taken from 90 samples:
45 sample with heart failure, and 45 normal healthy control. The age of individual ranged from (40-65)
years. The tryptase assay by ELISA technique. Total RNA Blood was determined by QIAamp RNA Blood
Mini Kits. Results: There are a very high significant increase in activity of tryptase and a high significant
decrease in the total RNA concentration in whole blood in heart failure patients group, in addition to a very
high significant decrease in the total RNA levels in whole blood heart failure patients group when compared
with normal subject. A highly significant in the activity of tryptase and a highly significant in the total RNA
levels in whole blood in heart failure (male, female) patients group when compared with (male, female)
normal subject. There are a highly significant in the serum activity of tryptase and highly significant in the
total RNA concentration in whole blood in patient group according to compared it with normal subject in
age 38-50 years and in age >50.
Conclusions: There was a correlation between tryptase levels and circulation total RNA levels and
development of major adverse HF events.
الدكتور فوزي حسن زاير الفهداوي | Dr.Fawzi Hasan Zayr Alfahdawi | 2210