عنوان المقالة:التقذير الطيفي للسيسابرايذ بالاعتماد على تكوين معقذ مسدوج أيوني مع كاشف بروموفينول الازرق Spectrophotometric determination of Cisapride Based on ionpair complex formation with Bromophenol blue
A new simple, sensitive and inexpensive method has been developed for the
spectrophotometric determination of cisapride in pharmaceutical formulation. The turbidimetric
method is based on the formation of the ion-pair complex between the drug and bromophenol
blue (BPB) in presence of potassium chloride at pH= 2.6, with a maximum absorbance at 520
nm. The calibration graph is linear in the concentration range 5-50μg.ml-1, with good correlation
coefficient (r = 0.9989).The limit of detection was found to be 1.14 μg.ml-1 and no interference
was observed from common excipients in the pharmaceutical preparation that contain cisapride
with good accuracy and precision.
رؤى مؤيد محمود | Ruaa Muayad Mahmood | 9684