عنوان المقالة:Allergic asthma is inversely associated with Helicobacter pylori seropositivity Allergic asthma is inversely associated with Helicobacter pylori seropositivity
Hasanain Abdulhameed Odhar*, Mohammed Abbas Hasan, Ali Mahmood Rayshan, Murtada Falah Hasan, Suqayna Habeeb Mahmmod, Huda Kahtan Majid
المؤلفون بالإنجليزي
Hasanain Abdulhameed Odhar*, Mohammed Abbas Hasan, Ali Mahmood Rayshan, Murtada Falah Hasan, Suqayna Habeeb Mahmmod, Huda Kahtan Majid
الملخص العربي
Background: Allergic asthma is a chronic inflammatory disease where the airways are characterized by hyper-responsiveness to certain allergens, mucus hyper-secretion and eosinophilic infiltration. These events are believed to be the inevitable outcome of imbalance between type 1 T helper (Th1) cells and type 2 T helper (Th2) cells responses. In asthma, exposure to specific allergens can elicit the release of allergic cytokines through upregulation of Th2 cells mediated pathway. Based on hygiene hypothesis, it is believed that exposure to exogenous pathogens can reduce asthma prevalence by shifting immune system balance toward domination of Th1 cells mediated response. In this trend, several studies have shown that Helicobacter pylori (H. pylori) infection can reduce prevalence of allergic asthma. This gram negative bacterium can amplify Th1 immune response through multiple mechanisms.
الملخص الانجليزي
Background: Allergic asthma is a chronic inflammatory disease where the airways are characterized by hyper-responsiveness to certain allergens, mucus hyper-secretion and eosinophilic infiltration. These events are believed to be the inevitable outcome of imbalance between type 1 T helper (Th1) cells and type 2 T helper (Th2) cells responses. In asthma, exposure to specific allergens can elicit the release of allergic cytokines through upregulation of Th2 cells mediated pathway. Based on hygiene hypothesis, it is believed that exposure to exogenous pathogens can reduce asthma prevalence by shifting immune system balance toward domination of Th1 cells mediated response. In this trend, several studies have shown that Helicobacter pylori (H. pylori) infection can reduce prevalence of allergic asthma. This gram negative bacterium can amplify Th1 immune response through multiple mechanisms.
Objective: The aim of this screening study is to explore any potential link between allergic asthma prevalence and H. pylori infection.
Methods: In this case-control study, we screened 30 asthmatic and 30 non-asthmatic volunteers for H. pylori IgG antibodies by immunohistochemical approach.
Results: the seropositivity of Helicobacter pylori IgG antibodies was significantly higher in non-asthmatic group (67%) than in asthmatic patients (37%); (P value = 0.009; Odds ratio = 5.50; confidence interval = 1.54-19.63).
Conclusions: Our findings significantly indicate that H. pylori infection is inversely associated with allergic asthma; it is also evident that absence of H. pylori infection can increase asthma risk by more than five times. Such possible association may be employed in future to design asthma preventive remedy by using H. pylori derived products.
محمد عباس حسن | Mohammed Abbas Hasan | 14033