Renal system is vital for total body homeostasis because the kidney plays a
principle role in the excretion of metabolic waste products and in the
regulation of extracellular fluid volume, electrolyte composition, and acidbase balance. Amikacin induced renal toxicity including a variety of
pathophysiological effects i.e. inflammation, specific transporters inhibition
,induction of oxidative stress and vascular alterations.Omega-3 fatty acids
are unsaturated fatty acids that have a roles in human physiology including
antioxidant and anti-inflammatory effects,. This study was designed to
examine the impact of co administration of omega 3 with therapeutic dose of
amikacin for 14 days in rats on amikacin nephrotoxic effect. The animals
utilized in this study were allocated into 3 groups (eight rats each) as
negative control group ,amikacin only group and omega 3 in concomitant
with amikacin group .serum creatinine, serum urea ,serum malondialdehyde(
MDA) and serum glutathione(GSH) levels were determined. The results
showed significant increase (P<0.05) in serum creatinine , urea and
malondialdehyde levels and significant decrease (P<0.05) in serum GSH level
in amikacin treated group compared to the corresponding level in negative
control group. Moreover, significant decrease in serum creatinine, urea, MDA
levels and significant increase in GSH level in group receiving omega3 with
amikacin in comparison with amikacin treated group. this study
demonstrated that co-administration of omega 3 with amikacin for 14 days
significantly alleviate the injurious effects of the intended antibiotic on rats'
kidneys.
م.د. هديل رشيد فرج | Dr.Hadeel Rashid Faraj | 4062