عنوان المقالة:تحضير ودراسة الفعالية البايولوجيه لمركبات حلقية جديدة مشتقة من الهيدرازايد Synthesis and Study the Biological Activity of New Heterocyclic compounds drived from hydrazided dreviatives
Wasan M. Abd-AL Hameed1, Jumbad H. Tomma2, Rajaa K. Baker3 1Post graduate, Department of Chemistry, College of Education for Pure Science / Ibn Al-Haith
الملخص العربي
تم تحضير مجموعة من المركبات الحلقية غير المتجانسة والمشتقه من مركبات الهيدرازيد وكذلك تم دراسة الفعاليه البايولوجيه لها وذلك بدراسة تاثيرها على مجموعة من البكتريا
الملخص الانجليزي
ersity of Baghdad Iraq, 3Ass. Prof. Department of Chemistry, College of Education for Pure Science / Ibn Al- Haitham/ University of Baghdad Iraq
Abstract
The work involves synthesis of new compounds derived from 2-substituted-3-thio- acetohydrazide- 1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazide compound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH led to formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetate to give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation new hydrazide compounds [VII]. Ring closure reaction of compound [VII] with 4-aminbenzoic acid in POCl3 give 1,3,4-oxadiazoles [VIII]. Compound [VIII] was reacted with sub. benzaldehyde to form compounds of Schiff bases [IX]a-d. The synthesized compounds were diagnosed via IR, Mass and 1HNMR spectral data. Many of synthesized compounds were examined against activity of antibacterial: gram (+) (Bacillus subtitis, staphylococcus aureus) and gram (-): (E.coli bacteria) and candida tropicalis fungial. To ensure the safety of the synthesis compounds the toxicity was examined
رجاء كاظم باقر | Rajaa Kadhium Baker or Baqir | 9676