The current study was conducted to evaluate the antimicrobial potential of different aqueous and alcoholic extracts of leaves Ziziphus (Ziziphus spina-christi), Eucalyptus (Eucalyptus camaldulensis) against reference strains of bacteria and mold. The chemical compound detection of Ziziphus plant leaves findings showed that aqueous and alcoholic extracts contain effective compounds that have been detected except composite resins in aqueous extract and resins in the alcoholic extract. The leaves of Eucalyptus plant aqueous and alcohol extracts contained resins, tannins, phenols. It tested the effectiveness of inhibitory extract plant against five isolates bacterial and five isolates of molds. The concentration of 50 and 100 mg / mL of extract rvealed zone of inhibition and efficiency increased with increasing concentration.