عنوان المقالة:الجمع بين فايروس مرض النيوكاسل, الريتوكسيماب والدكسوروبيمسين كعلاج لاورام الدم الخبيثه Newcastle disease virus, rituximab, and doxorubicin combination as anti-hematological malignancy therapy
أحمد مجيد حمزة الشمري | Ahmed Majeed Al-Shammari | 7350
نوع النشر
مجلة علمية
المؤلفون بالعربي
احمد مجيد الشمري, هدى رميز, مها الطائي
المؤلفون بالإنجليزي
Ahmed Majeed Al-Shammari, Huda Rameez, Maha F Al-Taee
الملخص العربي
Hematological malignancies are important diseases that need more powerful therapeutics. Even with current targeting therapies, such as rituximab and other chemotherapeutic agents, there is a need to develop new treatment strategies. Combination therapy seems the best option to target the tumor cells by different mechanisms. Virotherapy is a very promising treatment modality, as it is selective, safe, and causes cancer destruction. The Iraqi strain of Newcastle disease virus (NDV) has proved to be effective both in vitro and in vivo. In the current work, we tested its ability on anti-hematological tumors and enhanced current treatments with combination therapy, and studied this combination using Chou–Talalay analysis. p53 concentration was measured to evaluate the mechanism of this proposed synergism. The results showed that NDV was synergistic with doxorubicin in low doses on plasmacytoma cells, with no involvement of p53 pathways, but involved p53 when the combination was used on non-Hodgkin lymphoma cells. NDV in combination with rituximab showed enhanced cytotoxicity that was p53-independent. In conclusion, this work proposes a novel combination modality for treatment of some hematological malignancies.
تاريخ النشر
20/04/2016
الناشر
Dovepress
رقم المجلد
2016
رقم العدد
5
ISSN/ISBN
2253-1572
رابط DOI
10.2147/OV.S95250
الصفحات
27-34
رابط الملف
تحميل (114 مرات التحميل)
رابط خارجي
https://www.dovepress.com/newcastle-disease-virus-rituximab-and-doxorubicin-combination-as-anti--peer-reviewed-article-OV
الكلمات المفتاحية
oncolytic viruses, virotherapy, combination therapy
رجوع