عنوان المقالة: Synthesis, Spectral Characteristics, and Biological Activity of 1,3-Oxazepines and 1,3-Oxazepanes Derived from 6-Nitrobenzothiazol-2-amine
هيثم دلول حنون | Haitham Dalol Hanoon | 6544
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- الملخص الانجليزي
- 1,3-Oxazepine and 1,3-oxazepane derivatives of 6-nitrobenzothiazol-2-amine were synthesized, and their spectral and antibacterial properties were studied. The condensation of 6-nitrobenzothiazol-2-amine with aromatic aldehydes gave the corresponding Schiff bases, whose subsequent intermolecular cyclization with maleic and succinic anhydrides led to the target 1,3-oxazepine and 1,3-oxazepane derivatives. The compositions and structures of the synthesized compounds were established by elemental analysis and FTIR and 1H NMR spectroscopy. 2-(4-Hydroxy-3-methoxyphenyl)-3-(6-nitrobenzothiazol-2-yl)-1,3-oxazepane-4,7-dione and 2-(4-isopropylphenyl)- 3-(6-nitrobenzothiazol-2-yl)-1,3-oxazepane-4,7-dione showed the highest antibacterial activity against the gram-positive bacteria Klebsiella pneumonia and Bacillus subtilis, and the gram-negative bacteria Staphylococcus aureus provide to be highly sensitive to 2-(4-hydroxy-3-methoxyphenyl)-3-(6-nitrobenzothiazol- 2-yl)-1,3-oxazepane-4,7-dione.
- تاريخ النشر
- 24/04/2020
- الناشر
- Russian Journal of Organic Chemistry
- رقم المجلد
- 56
- رقم العدد
- 2
- رابط DOI
- https://doi.org/10.1134/S1070428020020244
- رابط خارجي
- https://doi.org/10.1134/S1070428020020244
- الكلمات المفتاحية
- benzothiazole, Schiff base, 1,3-oxazepine, spectral study, antibacterial activity