عنوان المقالة: The Protective Role of Toll‑Like Receptor Agonist Monophosphoryl Lipid A Against Vaccinated Murine Schistosomiasis
رباب سالم حمد | Rabab Salem Hamad | 10245
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- المؤلفون بالإنجليزي
- , Ibrahim Aly, Essam H. Ibrahim, Rabab S. Hamad, et al
- الملخص الانجليزي
- Purpose Schistosomiasis is a disease that aficts over 220 million people worldwide. To date, there is no vaccine against schistosomiasis and chemotherapy relies basically on a single drug, praziquantel. The current study was undertaken to investigate the therapeutic efects of monophosphoryl lipid A (MPLA) as an adjuvant in soluble egg antigen (SEA)-vaccinated and Schistosoma mansoni-infected mice. Methods Mice were divided into two groups of uninfected and Schistosoma mansoni infected. The two groups were treated diferently with MPLA, SEA and praziquantel. Study parameters included parasitological, immunological and biochemical parameters. Results Parasitological parameters revealed that intraperitoneal injection of MPLA into SEA-vaccinated and S. mansoniinfected mice was efective in reducing the worm and egg burden, granuloma count and diameter as well as the total area of infection in their livers versus SEA-untreated but infected ones. In addition, MPLA showed ameliorative action on the elevated liver oxidative stress marker, including malondialdehyde (MDA) and a decrease in the level of the antioxidant enzymes, reduced glutathione (GSH) and catalase (CAT) which may have a role in the liver damage and fbrosis due to S. mansoni infection. Conclusion Treatment with MPLA has multi-functions in attenuating the deleterious impacts of S. mansoni infection in mice livers. Its efects are mediated through a reduction of ova count, worm burden, granuloma diameter and amelioration of antioxidant defense systems, and liver function biomarkers
- تاريخ النشر
- 20/04/2020
- الناشر
- Springer
- رقم المجلد
- رقم العدد
- رابط DOI
- https://doi.org/10.2478/s11686-020-00204-3
- رابط الملف
- تحميل (269 مرات التحميل)
- الكلمات المفتاحية
- Schistosomiasis · Monophosphoryl lipid A (MPLA) · Chemotherapy · Oxidative stress · Antioxidant enzymes · SEA