عنوان المقالة: Construction of ion selective membrane electrodes for the potentiometric determination of enalapril maleate in its pure form and pharmaceutical preparations.
Two novel enalaprilmaleate (ENM) ion selective electrodes were constructed and used for the determination of ENM in its pure form and pharmaceutical formulations. The electrodes were based on the use of the ion association complexes of either phosphotungstic acid (PTA) or phosphomolybdic acid (PMA) as anions with Enalapril cation in a PVC matrix plasticizers with di-butyl phthalate (DBP).The results of these electrodes showed stability (life time 33 and 51 days), near Nernstian response (slope 57.2 and 52.2 mV/decade ), low detection limit (1.3×10-7and 4.2×10-7M )for DBP-ENM-PTA and DBP-ENM-PMA electrodes respectively.For both electrodes the best concentration for internal filling solution was 1×10-3 M ENM and the linear range was 1×10-5-1×10-1 M. The electrodeswere found to be usable within the pH range 2.2 – 3.8 and 2.5 – 3.0 for the above mentioned electrodes. This studyalso included the measurements of selectivity of these electrodes in the presence of common cations, anions and some drug excipients. The KPotJ,ifound to be less than 1.The electrodes were successfully applied for determination of ENMin pure form and in tablet pharmaceutical preparation with recovery of not less than 98 %.
أ.د. فدعم متعب عبدون | Prof Dr. Fadam Muted Abdoon | 3542