Sabah Mohamed Alharazy, Norella Kong, Rashidi Saidin, Abdul Halim Abdul Gafor, Oteh Maskon, Marlyn Mohd and Syed Zulkifli Syed Zakaria
الملخص الانجليزي
We investigated whether serum neutrophil gelatinase-associated lipocalin (NGAL) was an early predictive biomarker of contrast induced nephropathy (CIN) in patients with chronic kidney disease (n ¼ 100) undergoing coronary catheterization. Serum
creatinine (SCr) levels were measured at baseline, 24 hours, and 48 hours post procedure. Serum NGAL was measured pre-procedure, 4 hours, and 24 hours post procedure. The frequency of CIN was 11%. In patients with CIN, SCr achieved significance
only at 48 hours (P ¼ .006), whereas serum NGAL increased 25% from baseline at 24 hours in 7 of 11 patients with CIN (P ¼
.04) but did not change in the other 4. However, serum NGAL also rose 25% in 12 of 89 non-CIN patients. This subgroup could
have had ‘‘incipient CIN.’’ Serum NGAL delta value at baseline, 24 hours was superior to SCr for early diagnosis of CIN. In conclusion, serum NGAL is an early predictive biomarker for CIN.
د. صباح محمد الحرازي | Sabah Mohamed Alharazy | 3023