Research Journal of Pharmaceutical, Biological and Chemical Sciences
الملخص العربي
Ethyl-4-(4-(4-chlorophenylcarbamoyl)-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrmidine-5-
carboxylate 14, which is an analogous compound of Monastrol, has been synthesized within three steps. The first step was
done by synthesizing each of N-(4-chlorophenyl)-2-methoxy-4-methylbenzamide 10 and 2-methoxy-N-(4-methoxyphenyl)-
4-methylbenzamide 11 by means of coupling reaction that is used N,N
’
-dicyclohexylcarbodiimide 2 (DCC) and 1-
hydroxybenzotriazole 5 (HOBt) as coupling reagents. The methyl group of the compounds 10 and 12, which have a para
position, was oxidized to aldehyde by using selenium dioxide as an oxidizing agent to form N-(4-chlorophenyl)-4-formyl-2-
methoxybenzamide 12 and 4-formyl-2-methoxy-N-(4-methoxyphenyl)benzamide 13. The compound 14 was synthesized in
a one-pot reaction comprised of aldehyde product 12, ethyl acetoacetate, and urea which is called Biginelli reaction. The
synthesized compounds were being identified by different ways included the melting point, TLC technique, IR spectra,
1
H-
NMR spectrophotometer, and Elemental analysis.
أ. د ناظر نجم عبدالله الكطراني | Nadhir Najim Abdullah Jafar | 4473