عنوان المقالة:Major Signaling Pathways of Colorectal Carcinogenesis
سعد صبار دحام | Saad Sabbar Dahham | 8453
نوع النشر
فصل في كتاب
المؤلفون بالعربي
Yasser M Tabana, Saad S Dahham, Amin M Shah, Abdul Majid
الملخص العربي
Colorectal cancer (CRC) is one of the most aggressive malignant solid tumors which remain a rampant killer across the world. Toxic drugs have failed to reduce the morbidity and mortality rate of CRC patients. In addition, adoption of cancer-causing behaviors has increased the globule burden of CRC. The disease is characterized by extensive angiogenesis and perturbation of a variety of oncogenes and tumor suppressor genes including, p53, Wnt, hypoxia, NF-кB, Notch, MAP kinase and TGFβ. Targeting one or more of these signaling pathways increases the selectivity of the chemotherapeutic agents as these pathways are important for cancer cells growth and proliferation. Analysis the multi-step process of this malignant disease and understanding the underling signaling pathways will probably facilitate the efficacy of targeted therapy. Colorectal neoplasms can be prevented by interfering with the various steps of oncogenesis, which associated with uncontrolled epithelial cell replication, continues with the formation of adenomas and eventually evolves into malignancy. The knowledge described herein will help to understand the tumorigenesis signaling pathways of this disease and also will help to prevent or/and treatment CRC.
تاريخ النشر
10/05/2016
الناشر
Recent Advances in Colon Cancer
رابط خارجي
http://www.avidscience.com/wp-content/uploads/2016/04/RACOC-15-01.pdf
رجوع