masking and for protection against moisture and light. The elemental concentration of the film-coated content should be carefully monitored otherwise it can be toxic. In the present work, the toxicity of some commercial antidiabetic tablets available in Pakistan has been checked by precise quantitative analyses of their elemental content using a novel method. The proposed technique combines calibration free laser induced breakdown spectroscopy (CF-LIBS) and laser ablation time of flight mass spectrometer (LA-TOF-MS) without using aggressive chemicals. The thickness and chemical composition of coating films are analyzed using cross-sectional scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). It is observed that the film-coating on the German sugar cure cores (GSCC) tablets consist of aluminum (50–100) μm and titanium (500–800) μm. In addition, the thicknesses of Glucophage and Zolid Plus tablets’ coatings are found to range from 20–30 μm and composed of titanium, carbon, oxygen, sodium and magnesium. It has been found that a daily dose of three times a day of GSCC tablets contains about 600 mg/day of titanium and 150 mg/day of aluminum may considered toxic according to the United States food and drug administration (FDA). The results demonstrated that the core of the GSCC tablets mainly composed of calcium (60.7%), magnesium (24.2%), sodium (4.3%), potassium (2.5%), barium (2.4%) and silicon (5.8%) whereas, the core material in the Zolid Plus 850 mg and Glucophage 1000 mg tablets contain metformin (C4H11N5•HCl) with hydrogen (7.3%), carbon (29.1%), nitrogen (42.4%) and chlorine (21.2%). Inclusive analysis based on the innovated non-destructive metho
ا.د. وليد توفيق يونس | Prof. Walid Tawfik | 6356