عنوان المقالة: Formulation, characterization and in vitro release study of 5-fluorouracil loaded chitosan nanoparticles
د.مشيره سامى عبد العزيز يوسف | Dr.Moshera Samy Abdelaziz Youssef | 4141
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- المؤلفون بالإنجليزي
- Moshera Samy Sameh Hosam Abd El-Alim, Abd El Gawad Rabia , Amal Amin , Magdy M.H. Ayoub
- الملخص الانجليزي
- The main objective of this study was to evaluate the most suitable conditions to prepare 5-fluorouracil (5-FU) loaded chitosan nanoparticles (CSNPs). 5-FU loaded CSNPs were prepared employing the ionic gelation technique using three different molecular weights of CS with the polyanion sodium tripolyphosphate (STPP) as cross-linking agent. The preparation was based on the ionic interaction of positively charged CS and negatively charged STPP. The entrapment efficiency (EE%) of CSNPs was in the range of 3.86–21.82% EE% exhibited a clear increasewith increasing CS concentration. The averge particles sizewas in the nanosize range and monodisperse in naturewhereas transmission electronmicroscopemicrographs showed that the prepared nanoparticles have a spherical shape. Fourier transforminfrared (FTIR), X- ray differaction (XRD) and differential scanning calorimetry (DSC) confirmed successful incorporation of 5-FU in prepared CSNPs. In vitro release of 5-FUfromselected formulations exhibited sustained release from the nanoparticles where slower release was observed when highermolecular weight CS was used. The study of drug release kinetics revealed that the release of 5-FU from CSNPs followed a diffusion controlled pattern.
- تاريخ النشر
- 05/08/2020
- الناشر
- International Journal of Biological Macromolecules
- رقم المجلد
- رقم العدد
- الصفحات
- 783–791
- رابط الملف
- تحميل (0 مرات التحميل)
- رابط خارجي
- https://www.sciencedirect.com/science/article/abs/pii/S014181302032972X
- الكلمات المفتاحية
- Ionic gelation Chitosan 5-Fluorouracil