عنوان المقالة:Bioactive essential oils from Aquilaria crassna for cancer prevention and treatment
سعد صبار دحام | Saad Sabbar Dahham | 8453
نوع النشر
مؤتمر علمي
المؤلفون بالعربي
S.S. Dahham, M.B.K. Ahamed, S.M. Saghir, F.S. Alsuede, M.A Iqbal, A.M.S.A. Majid
الملخص العربي
Aquilaria crassna has been used as a traditional medicinal plant to treat infectious and inflammatory diseases. The present study was aimed to investigate the chemical profile of ethanol extract of A. crassna stem bark with respect to the in vitro antioxidant and anti-cancer properties. Phytochemical analysis showed that the ethanol extract of A. crassna is enriched with phenolic compounds (40.8% dry weight per gram of extract) followed by flavonoids (15.9%), triterpenoids (10.5%), alkaloids (9.8%), saponins (4.1%) and tannins (3.1%). The extract demonstrated significant antioxidant effects with IC50 values 62.8, 89.4 and 43.1 µg/ml in DPPH, ABTS and FRAPS assays, respectively. The results were comparable with that of ascorbic acid. Furthermore, the extract demonstrated potent anti-proliferative effect with IC50 30, 72, 119 and 140 µg/ml against pancreatic (PANC- 1), prostrate (PC3), colorectal (HCT 116) and breast (MCF-7) cancer cells, respectively. The extract showed considerable anti-proliferative activity against human endothelial cells (HUVEC) with IC50 48 µg/ml. GC-MS analysis revealed that the extract is enriched with diversified constituents majorly belong to essential oils, phenolics and flavonoids. It can be concluded that the anti-oxidant and anticancer effects of the extract could be due to the cumulative effect of the biologically active phytoconstituents present in the extract of A. crassna stem bark
تاريخ النشر
10/05/2014
الناشر
Global Journal on Advances Pure and Applied Sciences
رابط خارجي
https://www.researchgate.net/profile/Saad_Dahham/publication/267437294_Bioactive_essential_oils_from
الكلمات المفتاحية
medicinal, Aquilaria, infectious, phenolic, prevention.
رجوع