عنوان المقالة:دراسة تأثير فيتأمين E على تصلب الشرايين في تجربة الارانب مرتفعة الكولستيرول A study effect of Vitamin E on atherosclerosis in Experimental Hyper cholesterol emic Rabbits
زيد مهدي محمد جامعة الكوفة/ كلية الزراعة / قسم علوم الاغذية أ.د. نجاح رايش الموسوي جامعة الكوفة/ كلية الطب / فرع الادوية والعالجيات أ.م.د. عدنان وهاب المظفر جامعة الكوفة / كلية الزراعة / قسم علوم الاغذية
المؤلفون بالإنجليزي
Zaid M Mohammed Department of Food Science, College of Agriculture/Kufa University Najah R Hadib Department of Pharmacology and Therapeutics/College of Medicine/ Kufa University Adnan W Al Mudhafar Department of Food Science, College of Agriculture/Kufa University
الملخص العربي
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الملخص الانجليزي
Background: Atherosclerosis remain as a major health problem occasioning early death in much of the world's people. The ancestry of this diseases related to genetic influences and dietary improperly. The main sourcesof dietary cholesterol are eggs, meat, and milk products,
which induced hypercholesterolemia and atherosclerosis insome species of animals.Materials and Methods : Eighteen local domestic malerabbits will be randomly allocated into 3 groups, 6 in eachGroup: Group I (n = 6), control; Group II (n = 6), Rabbit fed1% cholesterol-diet (induced untreated group); Group III (n= 6), 1% cholesterol-diet + Vitamin E (400 mg/kg dailyorally). Blood samples were collected at zero time, after fourweeks and after eight weeks on experimental diets formeasurement of serum triglycerides (TG), total cholesterol(TC), HDL-C and serum IL-6, serum high sensitive CReactive Protein hs-CRP.
Results: Compared with the control group, levels of TC,TG, LDL-C, VLDL-C, hs-CRP, IL-6 were increased andHDL-C were decreased in the animals with a high-fat diet (P< 0.05). Histologically all induced-untreated rabbit showedinqrease aortic intima-media thickness (P < 0.05). Vitamin Etreatedgroup showed significant effects on lipid parametersin comparing with induced untreated group (P < 0.05).Vitamin E counteract the change in hs-CRP, IL-6 incompare with induced untreated group (P < 0.05).
تاريخ النشر
05/09/2018
الناشر
AL-utroha for agricultural and veterinary
رقم المجلد
1
رقم العدد
7
الصفحات
103 - 116
الكلمات المفتاحية
: Vitamin E, atherosclerosis, inflammation, lipid profile
الاستاذ الدكتور عدنان وهاب المظفر | Prof. Dr. ADNAN WAHHAB AL-MUDHAFAR | 4744