Ibtisam M. Ahmed , Suad A. Gadir, Elsheikh E. Elgilany and Taguldien M. Abdallah
الملخص العربي
ABSTRACT
Medicinal plants are the richest bio-resources of drugs. There is need to validate medicinal and
aromatic plants researches results through an organized database.
Objective: To identify the terpenoids in Commiphora africana resin and some biological activity
specially antiviral activity.
Materials and Methods: Two different methods were done to identify Terpenoids in this resin,
dipping the resin in CH2Cl2 and isolation using column chromatography [1], ethanol and water
extract were extracted for phytochemical screening and the biological aspects.
Results: Phytochemical screening identified that Flavonoids, Saponins, Alkaloids and Terpenes
were the major constituents of C. africana resin ethanolic and water extracts. GC-MS analysis of
CH2Cl2 extract and the isolated samples by column chromatography revealed compounds which
Original Research Article
Ahmed et al.; EJMP, 13(3): 1-11, 2016; Article no.EJMP.22531
2
can play important role in therapy, so as Betulin C30H50O2. Urs-12-en-28-al, 3-(acetyloxy) C32H50O3.
Cholest-22-ene-21-ol, 3-5-dehydro-6-methoxy-, pivalate C33H54O3 and Phthalic acid, bis(2-pentyl)
ester C18H26O4. LC50 values of water and ethanolic extracts were found to be 100 and 630.9
respectively. While the LC50 for the aqueous water solution of the crude resin was found to be
63.1.
High and clear antiviral activity towards Newcastle virus was observed at 400 ug/ml C. africana
water solution, 400 ug/ml C. africana water extract and 100, 200, 400, 500 ug/ml C. africana
ethanol extract. The highest antimicrobial activity recorded was obtained for C. africana ethanol
extract against Staphylococcus aureus, Klebsiella porwonia, Asperogillus niger and Candida
Albicans.
Conclusion: Antiviral activity shown by Commiphora africana resin extracts may be due to
different compounds included.
ابتسام محمد احمد محمود | EBTISAM MOHAMED AHMED MAHMOUD | 6419