عنوان المقالة:مركبات غير حلقية من الجزء الفعال بيولوجيا من مستخلص أزهار نبات الألبيزيا لبخ "دقن الباشا" New acyclic secondary metabolites from the biologically active fraction of Albizia lebbeck Flowers
محمد فرج عبد الحليم عبد الله | Mohamed Farag Abd El Halim Abd Alla | 5474
- نوع النشر
- مقال علمي
- المؤلفون بالعربي
- المؤلفون بالإنجليزي
- Shaza M. Al-Massarania, Ali A. El Gamala,b*, Mohamed Farag, Mansour S. Al-Saida, Maged S. Abdel-Kaderc, Omer A. Basudana, Saleh I. Alqasoumi
- الملخص العربي
- The total extract of Albizia lebbeck flowers was examined in vivo for its possible hepatoprotective activity in comparison with the standard drug silymarin at two doses. The higher dose expressed promising activity especially in reducing the levels of AST, ALT and bilirubin. Fractionation via liquid- liquid partition and reexamination of the fractions revealed that the n-butanol fraction was the best in improving liver biochemical parameters followed by the n-hexane fraction. However, serum lipid parameters were best improved with CHCl3 fraction. The promising biological activity results initiated an intensive chromatographic purification of Albizia lebbeck flowers fractions. Two compounds, identified from natural source for the first time, the acyclic farnesyl sesquiterpene glycoside1-O-[6-O--L- arabinopyranosyl--D-glucopyranoside]– (2E,6E-) -farnesol (6) and the squalene derivative2,3-dihydroxy-2,3-dihydrosqualene (9), in addition to eight compounds reported here for the first time from the genus Albizia; two benzyl glycosides, benzyl 1-O--D- glucopyranoside (1) and benzyl 6-O--Larabinopyranosyl -D-glucopyranoside (2); three acyclic monoterpene glycosides, linalyl - D- glucopyranoside (3) and linalyl 6-O--L-arabinopyranosyl - -D-glucopyranoside (4); 2E)-3,7-dimethylocta-2,6-dienoate-6-O--L arabinopyranosyl- -D-glucopyranoside
- تاريخ النشر
- 17/01/2017
- رقم المجلد
- رقم العدد
- رابط DOI
- http://dx.doi.org/10.1016/j.jsps.2016.05.006
- رابط الملف
- تحميل (106 مرات التحميل)
- الكلمات المفتاحية
- Albizia lebbeck