عنوان المقالة:تأثير السينكتيد - محفز مستقبلات النيوروكينين 3 - على وظائف المبايض في إناث الأبقار Effects of senktide, a neurokinin-3 receptor agonist, on ovarian functions in cows
أحمد سعد أحمد حسانين - شوتشي ماتسوياما - ماساهيرو كاتو - يوتا سيتومي - ريوسوكيه ميزو - شينيا أويشي - هيروكو تسوكامورا - شاتوشي أوكرا
المؤلفون بالإنجليزي
Ahmed Saad Ahmed Hassaneen, Shuichi Matsuyama, Masahiro Kato, Yuta Suetomi, Ryosuke Misu, Shinya Oishi, Hiroko Tsukamura, Satoshi Ohkuraa
الملخص العربي
بحث تم عرضه عرض تقديمي في المؤتمرالعلمي الدولي الثالث للعلوم الطبية البيطرية وتناول البحث استخدام السينكتيد في تحسين الخصوبة في الماشية عن طريق تحسين وظائف المبايض ورفع كفاءة التبويض
الملخص الانجليزي
Recent studies suggest that hypothalamic neurokinin B (NKB)/neurokinin-3 receptor
(NK3R) signaling has an essential role in regulating gonadotropin-releasing hormone (GnRH)
release via control of kisspeptin/NKB/dynorphin A (KNDy) neuronal activity. The present study
aimed to examine the effects of senktide, a highly selective NK3R agonist, on gonadotropin
release, follicular development, and ovulation during the follicular phase in cows. Cows (n=12)
during follicular phase were intravenously administered with senktide (30 or 300 nmol/min) or
vehicle for 2 h, and blood samples were collected every 10 min for 24 h from 8 h before to 16 h
after the onset of the senktide infusion for analysis of luteinizing hormone (LH) and folliclestimulating hormone (FSH). Follicular growth and ovulation were examined by the transrectal
ovarian ultrasonography. Plasma LH concentration increased immediately after the senktide (300
nmol/min) infusion and showed sustained increase for 6-8 h. Two out of 4 cows treated with high
dose of senktide showed high LH release response. Plasma FSH concentrations showed sustained
increase in high dose group. Low dose of senktide failed to stimulate LH and FSH secretions.
High dose of senktide induced early ovulation in 2 out of 4 cows. Taken together, this study
suggests that administration of senktide could be a useful approach to induce follicular
development and ovulation for treatment of reproductive failures and improve the reproductive
fertility in cows.
تاريخ النشر
06/08/2018
الناشر
3rd International Conference of Veterinary Sciences-Role of Veterinary Medicine in Community Service “Hopes and challenge
أحمد سعد أحمد حسانين | Ahmed Saad Ahmed Hassaneen | 7586