عنوان المقالة:Association of Estrogen-metabolizing Gene polymorphisms CYP 1A1 MspI (rs 4646903) and CYP C17 (rs 11191548) with breast cancer in Iraqi patients
Abdul Hussein A. Algenabi, Hamed Jadoa Abbas, Talib Hussein Kamona
الملخص العربي
Abstract: Estrogen has been proposed to trigger breast cancer development.
Increase or prolong exposure to estrogen can damage the DNA molecule and
increase the genomic instability process in breast tissue. To examine this
hypothesis, case-control study was conducted to determine whether
polymorphisms of the genes responsible for estrogen biosynthesis (CYP17) and
hydroxylation (CYP1A1) are associated with an elevated risk for breast cancer in
Iraqi women. Three hundred breast cancer women and 170 healthy controls were
recruited. Polymerase chain reaction– restriction fragment length polymorphism
(PCR- RFLP) assays were used to determine the genotypes of estrogenmetabolizing
genes. The homozygous mutant genotypes (vtvt) of CYP 1A1 in
codominant was significantly increased the risk of breast cancer to 3.34 folds with
respect to those of the wild type (wtwt). The homozygous mutant genotype
(A2A2) of CYP 17 in codominant was significantly increased the risk of breast
cancer 3.86 folds with respect to those of the wild type (A1A1). The findings of
this study revealed that CYP1A1 and CYP17 genes polymorphisms were
associated with breast cancer in Iraqi women.
تاريخ النشر
30/11/2012
الناشر
Journal of Chemical, Biological and Physical Sciences
د. حامد جدوع عباس | Dr. hamed Jaddoa Abbas | 14453