عنوان المقالة:تقييم النشاط المضاد للقرحة للإندول - 3 كاربينول و / أو أوميبرازول على قرحة المعدة التي يسببها الأسبرين في الجرذان Evaluation of antiulcer activity of indole-3-carbinol and/or omeprazole on aspirin-induced gastric ulcer in rats
نشوى الشناوي و سميرة عبد المجيد وعيدة مفتاح الشيلابي
المؤلفون بالإنجليزي
Nashwa A. El-Shinnawy, Samira A. Abd-Elmageid and Eda M. A. Alshailabi.
الملخص العربي
لا يوجد له ملخص عربي
الملخص الانجليزي
Abstract
The present work is an attempt to elucidate the antiulcer activity of indole-3-carbinol (I3C), which is one of the
anticarcinogenic phytochemicals found in the vegetables of Cruciferae family such as broccoli and cauliflower,
alone or in combination with omeprazole (OMP), a proton pump inhibitor, to diminish the effects of induced
acute gastric ulcer by aspirin (ASA) in male albino rats. A total of 48 adult male albino rats were used in the
present study. Animals were divided into eight experimental groups (six animals each group). They were given
different experimental inductions of ASA at a dose of 500 mg/kg/body weight, OMP at a dose of 20 mg/kg/body
weight and I3C at a dose of 20 mg/kg/body weight either alone or in combination with each other orally for a
duration of 7 days. Inner stomach features, ulcer index, pH activity, body weight, stomach weight, hematological
investigations, serum total protein albumin and reduced glutathione activity were investigated in addition
to the histological, histochemical and immunohistochemical stain of cyclooxygenase-2 to the stomach tissue of
normal control, ulcerated and treated ulcerated rats. The results of this study revealed that oral administration
of ASA to rats produced the expected characteristic mucosal lesions. OMP accelerated ulcer healing but the
administration of I3C either alone or in combination with OMP to ASA-ulcerated rats produced a profound
protection to the gastric mucosa from injury induced by ASA. Our results suggested that administration of
antiulcer natural substances such as I3C in combination with the perused treatment such as OMP is a very
important initiative in the development of new strategies in ulcer healing.
ا.د. عيدة مفتاح عبدالكريم الشيلابي | Prof. Dr. Eda M. A. Alshailabi | 6162