عنوان المقالة:دراسة التداخلات الجزيئية لمضاد حيوي مع محاليل سكرية عند درجات حرارية مختلفة Study of Molecular Interaction for Antibiotic Drug with Sugar Solutions at Different Temperature
د.سندس هادي مرزا | dr.Sundus Hadi Merza | 12520
نوع النشر
مجلة علمية
المؤلفون بالعربي
سندس هادي مرزا نغم حميد عبود احمد محمد عباس
المؤلفون بالإنجليزي
Sundus H.Merza , Nagham H.Abood , Ahamed M. Abbas
الملخص الانجليزي
The interactions of drug amoxicillin with maltose or galactose solutions with a variation of temperature have been discussed by taking in the volumetric and viscometric procedures. Physical properties [densities (ρ) and viscosities (η)] of amoxicillin (AMOX) aqueous solutions and aqueous solutions of two type saccharides (maltose and galactose 0.05m) have been measured at T = (298.15, 303.15 and 308.15) K under atmospheric pressure. The apparent molar volume (φv cm3mole-1) has been evaluated from density data and fitted to a Redlich-Mayer equation. The empirical parameters of the Mayer-Redlich equation and apparent molar volume at infinite dilution Ø°v were explicated in terms of interactions from type solute-solvent and solute–solute interactions. Transfer molar volume ΔtraØ°v for AMOX from water to aqueous maltose and galactose solutions were calculated to comprehend different interactions in the ternary solutions. Limiting apparent molar expansibility (Ø°E) and Hepler’s coefficientwas also calculated to indicate the structure making ability of AMOX in the ternary solutions.Jones–Dole coefficient B and A have been calculated from viscosity data by employing the Jones–Dole equation. The free energy of activation of viscous flow per mole of the solute (Δμ°2*) and solvent (Δμ°1*) have been explained on the basis of the Eyring and Feakins equation.
تاريخ النشر
25/03/2020
الناشر
International Journal of Drug Delivery Technology
رقم المجلد
10
رقم العدد
1
ISSN/ISBN
0975-4415
الصفحات
170-174
رابط الملف
تحميل (287 مرات التحميل)
الكلمات المفتاحية
Amoxicillin, Apparent molar volume, Jones–Dole equation, Redlich-Mayer equation, Saccharide
رجوع