عنوان المقالة:التأثير الوقائي للاندول - 3-كاربينول ضد ضرر الاثني عشر المتسبب بواسطة الأسبرين في الجرذان. Protective Effect Of Indole-3-carbinol Against Aspirin Induced Duodenal Damage In Rats.
The aim of this study was to evaluate the protective effect of indole-3-carbinol on aspirin induced duodenal damage in male albino rats. Animals were divided into four groups. The first group was received distilled water and served as normal control group, the second group was received the aspirin (ASP) at a dose of (500 mg/kg/body weight), third group was received indole-3-carbinol (I3C) at a dose of (20 mg/kg/body weight), and the fourth group was received ASP (500 mg/kg/body weight) + I3C (20 mg/kg/body weight) for seven consecutive days. Histopathological study of duodenum tissue of rats administrating aspirin for 7 days showed desquamation in the lining mucosal epithelium associated with inflammatory cells infiltration in the underlying lamina propria of the mucosa, submucosa and muscularis. Sections of duodenum from rats treated with I3C or ASP+I3C showed the normal mucosa with no histopathological alteration. The present study provides a strong evidence of indole-3-carbinol produced a deep permanent protection from aspirin induced duodenal damage.
د. عيدة مفتاح عبدالكريم الشيلابي | Dr. Eda M. A. Alshailabi | 5875