Fluorescent semiconductor quantum dots (QDs) are nanocrystals with a diameter that usually ranges from 1 to 10 nm. QDs can be prepared by many techniques including plasma synthesis, mechanical fabrication, or colloidal synthesis. The current paper presents the synthesis of CdTe quantum dots (QDs) with wet chemical method at variable reaction time, variable temperature and variable trioctylphosphine (TOPO) concentration, to control the size of the produced QDs. Structural characterization was carried out with conventional transmission electron microscopy (TEM) and X-ray diffraction (XRD).