An aqueous medium multicomponent synthesis of trans-2-aroyl-5-methyl-3-aryl-3, 5-dihydrofuro [3, 2-c]-quinolin-4(2H)-one in pyridine by conventional and microwave irradiation, easy workup, smaller reaction time and lack of column chromatography are the significant feature of this protocol. The Phenacyl bromide with pyridine is first time used as starting with1-methyl-4-hydroxy quinolone, substituted aromatic aldehydes for the biological interest compound (4a-p) for this green transformation generating one C-O and two C-C bonds in one operation, Knoevenagel followed by Michael addition and intramolecular Cyclisation.
د / ممتاز السيد محمد بخيت | Momtaz El-sayed Mohamed Bakheet | 10887