عنوان المقالة:تعبير FAS في نسيج مرضى سرطان القولون و المستقيم و ارتباطها ببعض المعلمات المرضية السريرية Fas Expression in Colorectal Cancer Tissue of Iraqi Patients and its Correlation to Some Clincopathological Parameters
Colorectal cancer is one of the important public health problems in Iraq. It’s considered as the 7th among the commonest 10 cancers by site according to the Iraqi cancer registry. Studying the fas positive expression in colorectal cancer patients and its correlation to some clincopathological parameters was our agenda.
In this study, 50 colorectal cancer samples (paraffin embedded sections) were used to detect fas protein positive expression using Immunohistochemical technique .The correlation between fas positive expression with site, type and grading was also included . The results showed that there was no significant difference (p<0.05) between the fas protein positive expression of the cancerous tissue compared to the resection margin which explained as an immune evading mechanism done by the colorectal cancerous cells while in grading there was a significant difference (p<0.05) in the correlation between the well and moderately differentiated cancerous cells and not the poorly differentiated one , which may be due to the expression of the mutant type of the concerned protein.
In conclusion, the positive expression of the fas protein and its correlation to some clincopathological parameters can be used as a tool for the prognosis of the colorectal cancer cases.
تاريخ النشر
12/03/2012
الناشر
__International Journal for Sciences and Technology
احمد رشدي عبد الله | Dr Ahmed Rushdi Abdullah | 2716