عنوان المقالة:In vivo anti-inflammatory activity of β-caryophyllene, evaluated by molecular imaging
سعد صبار دحام | Saad Sabbar Dahham | 8447
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- Saad Sabbar Dahham, Yasser M. Tabana, Mohamed B. Khadeer Ahamed, Amin M.S. Abdul Majid
- الملخص العربي
- We have recently reported that β-caryophyllene (BCP) can suppress metastasis of colon cancer, induce apoptosis, and inhibit a broad spectrum of microorganisms. Here, we report anti-inflammatory effect of BCP in the carrageenan-induced edema paw model, supported by molecular imaging using fluorescence molecular tomography (FMT). A significant (p<0.01) reduction in paw volumes, and low intensity of fluorescent signal was noted in experimental animals when compared with negative control. Noteworthy, the low toxicity of BCP and its high ability of skin penetration attributed to the strong anti-inflammatory and analgesic properties. Intriguingly, BCP is a natural component of many volatile plants, spices,foods and major constituent of Cannabis, which is recognized as natural selective agonist to the CB2 receptor. Collectively, the result of present study illustrate that the anti-inflammatory properties of BCP could be beneficial for prevention and management inflammation-related diseases.
- تاريخ النشر
- 10/05/2015
- الناشر
- Molecules & Medicinal Chemistry
- رابط DOI
- doi: 10.14
- رابط خارجي
- http://www.smartscitech.com/index.php/mmc/article/view/1001/pdf_5
- الكلمات المفتاحية
- β-caryophyllene; FMT; anti-inflammatory