عنوان المقالة:تقدير مزيج من الاسبرين والكودائيين طيفيا Simultaneous Spectrophotometric Determination of Aspirin and Codeine
احمد مهدي سعيد محمد | Ahmed Mahdi Saeed Mohammed | 8733
نوع النشر
مجلة علمية
المؤلفون بالعربي
احمد مهدي سعيد, نور قاسم احمد
المؤلفون بالإنجليزي
Ahmed Mahdi Saeed and Noor Qasim Ahmed
الملخص العربي
يتضمن البحث تقدير مزيج من عقاري الاسبرين والكودائيين كمزيج في المستحظرات الصيدلانية باستخدام الطرق الطيفية
الملخص الانجليزي
A novel, accurate, and simple UV – spectrophotometric method for simultaneous determination of Aspirin (ASP) and Codeine (COD) in mixture of standard and tablets formulation was investigated in this work without any separation method between the drugs. The absorption maxima of drugs in mixture were found to be at ( 238 nm and 278 nm) for ASP and COD respectively, in deionized water: acetonitrile mixture (H2O: ACN 90:10 v/v) as solvent. These wavelengths were selected for the analysis of drugs as mixture standard and formulated samples. The purposed method is linear in the concentration range of ( 0.3 – 30 μg/mL) for ASP and COD in the mixture, with R2 values of (0.9992, 0.9991 ) for ASP and COD respectively. Recovery means were found to be (100.13, 99.81 ) for ASP and COD respectively. The method was applied for the estimation of the active gradient of the drugs in different samples of formulated dosage. The accuracy of method was validated by mean percentage recovery which was found to be in the acceptable range. .
تاريخ النشر
01/04/2017
الناشر
Research Journal of Pharmaceutical, Biological and Chemical Sciences
رقم المجلد
8
رقم العدد
4
ISSN/ISBN
0975-8585
الصفحات
1137-1143
رابط الملف
تحميل (188 مرات التحميل)
الكلمات المفتاحية
Novel, Simultaneous, Formulated, Recovery.
رجوع