عنوان المقالة: .Study the effect of a drug depakene (Valproic acid) in the serum levels of immune proteins in albino male rats
وجدان ابراهيم عباس عبدالوهاب | Wijdan I. A. Abd-alwahab | 7453
نوع النشر
مجلة علمية
المؤلفون بالعربي
المؤلفون بالإنجليزي
Wijdan IA Abd-alwahab, Zaid MM Al-Mahdawi and Sahib J Abdoul-Rahman
الملخص الانجليزي
This study aimed to investigate the effect of administration of depakene (valproic acid)(VPA)(15 mg/Kg of body weight, orally) on serum protein levels, including immune proteins, because its functions and the importance of these proteins in the body and they are overlapping, and that was by measured protein levels before and after treatment as concentrations of total protein (Tp), albumin and globulin in normal male rats and in rats that treated with VPA drug along the period of experiment (30) days. The results showed a significant decrease (P< 0.05) in concentrations of total protein and albumin in comparison with normal control group, whereas did not observe significant differences (P< 0.05) in globulin concentration compared with normal control group, despite of, there was a little decrease in globulin concentration in rats group that administrated the drug under study but non-significant. It could be concluded of the present study that the VPA drug have an greater side effects on concentration and function of proteins in serum, and subsequently, may extending these effects to comprise its effect on the immunity, osmotic pressure, blood volume, nutrients exchange between the blood and tissues, glomerular infiltration rate, transport many of materials and hormones, and several of physiological and biochemical functions which correlated with the serum proteins
تاريخ النشر
18/09/2018
الناشر
Tikrit Journal of Pure Science
رقم المجلد
20
رقم العدد
4
ISSN/ISBN
2415-1726
الصفحات
42-46
رابط خارجي
http://tjps.tu.edu.iq/index.php/j/article/view/248
الكلمات المفتاحية
.Depakene, VPA, Total protein, Albumin, Globulin
رجوع