عنوان المقالة:Bioactive essential oils from Aquilaria crassna for cancer prevention and treatment
سعد صبار دحام | Saad Sabbar Dahham | 8447
- نوع النشر
- مؤتمر علمي
- المؤلفون بالعربي
- S.S. Dahham, M.B.K. Ahamed, S.M. Saghir, F.S. Alsuede, M.A Iqbal, A.M.S.A. Majid
- الملخص العربي
- Aquilaria crassna has been used as a traditional medicinal plant to treat infectious and inflammatory diseases. The present study was aimed to investigate the chemical profile of ethanol extract of A. crassna stem bark with respect to the in vitro antioxidant and anti-cancer properties. Phytochemical analysis showed that the ethanol extract of A. crassna is enriched with phenolic compounds (40.8% dry weight per gram of extract) followed by flavonoids (15.9%), triterpenoids (10.5%), alkaloids (9.8%), saponins (4.1%) and tannins (3.1%). The extract demonstrated significant antioxidant effects with IC50 values 62.8, 89.4 and 43.1 µg/ml in DPPH, ABTS and FRAPS assays, respectively. The results were comparable with that of ascorbic acid. Furthermore, the extract demonstrated potent anti-proliferative effect with IC50 30, 72, 119 and 140 µg/ml against pancreatic (PANC- 1), prostrate (PC3), colorectal (HCT 116) and breast (MCF-7) cancer cells, respectively. The extract showed considerable anti-proliferative activity against human endothelial cells (HUVEC) with IC50 48 µg/ml. GC-MS analysis revealed that the extract is enriched with diversified constituents majorly belong to essential oils, phenolics and flavonoids. It can be concluded that the anti-oxidant and anticancer effects of the extract could be due to the cumulative effect of the biologically active phytoconstituents present in the extract of A. crassna stem bark
- تاريخ النشر
- 10/05/2014
- الناشر
- Global Journal on Advances Pure and Applied Sciences
- رابط خارجي
- https://www.researchgate.net/profile/Saad_Dahham/publication/267437294_Bioactive_essential_oils_from
- الكلمات المفتاحية
- medicinal, Aquilaria, infectious, phenolic, prevention.