عنوان المقالة:Synthesis and biological activity of new derivatives of 6-chloro-5-((4- chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy- N, N-dimethylpyrimidin-2-amine
أ. د ناظر نجم عبدالله الكطراني | Nadhir Najim Abdullah Jafar | 4417
- نوع النشر
- مجلة علمية
- المؤلفون بالعربي
- IOSR Journal of Pharmacy
- الملخص العربي
- 6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,N- dimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives, employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic acids in the presence of palladium tetraacetate, PhP 3 and Na 2 CO 3 in refluxing n-propanol afforded the target compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have been screened for their inhibitory activity against some microbial, the results were showed that among gram positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4. Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and C. glabrata isolate were resist these compounds.
- تاريخ النشر
- 23/02/2014
- الناشر
- Sai Scientific Communications
- رابط DOI
- Non
- رابط الملف
- تحميل (171 مرات التحميل)
- رابط خارجي
- IOSR Journal of Pharmacy (IOSR-PHR) http://www.iosrphr.org/
- الكلمات المفتاحية
- Pyrimidine, arylboronic acid, synthesis, Suzuki, gram positive