The effect of injection of some mediators on the blood values of ewes was studied during postpartum and lactation period. The study was
conducted on 30 pregnant ewes aged 3-5 years, presented in the farms of the college of veterinary Medicine/ AL-Fallujah University during
the period from February 2014 to August 2015. Ewes were divided into three equal groups (10 each). The first group was injected with
prostaglandin F2α (PGF2α) and the second group injected with oxytocin the injection was done after the ewe’s birth directly, the third group
was treated as a control group. Blood values were measured during the first and third week after birth which included (red blood cell count
(RBC), hemoglobin (Hb), Packed cell volume (PCV), erythrocyte sedimentation rate (ESR), mean cell volume (MCV), mean cell hemoglobin
(MCH), mean cell hemoglobin concentration (MCHC), white blood cell count (WBC), WBC differential count).Results show that RBC
(329.8±25.59), PCV (28.75±0.86), MCV (1.22±0.08), were in their high rate in the group of ewes injected with PGF2α than other group also
high in oxytocin injected group than control which induct the role of PGF2α in the increasing some blood values than other mediators throw
increasing utilities of corpus luteum and decreasing the time of uterine involution so that bleeding after birth will stop in a short time,
Oxytocin came in the second place after PGF2α in terms of the it’s effect of raising the blood values after birth and lactation period. The effect
of PGF2α and oxytocin was the same on Hb concentration in treated ewes. ESR used in this study to show the difference because it not
concerned in the study of blood values in domestic animals. WBC count (6330±241.1) were high in G1 than other groups. No significance in
Neutrophil and Lymphocyte values in all groups, while the results of Basophil and Monocyte were the highest in G1, Eosinophil were higher
in G2