م.د.رويدة سمير سعيد ,أ.م.د. فاضل سليم متي , أ.د.علي حمادي سمير
المؤلفون بالإنجليزي
Ruwaidah S. Saeed , Fadhel S. Matty and Ali H. Samir
الملخص الانجليزي
Schiff bases [1]a,b were prepared from the reaction of 2-amino-5-mercapto-1,3,4-thiadiazole with aromatic aldehydes . In the present study a series of some four , five-and seven-membered heterocyclic compounds have been synthesized by the reaction of schiff bases [1]a,b with thioglycolic acid , chloroacetyl chloride , sodium azide or various anhydrides to give thiazolidinone [2]a , azetidinone [6]b , tetrazole [7]b and 1,3-oxazepine derivatives [14-16]b respectively , then compounds[2]a , [6,7]b and[14-16]b were reacted with Na2CO3 of distilled water as a solvent, then of ClCH2COOH was added to produce [3]a , [8,9]band[17-19]b . The compounds [3]a , [8,9]b and [17-19]b reacted with SOCl2 in the presence of Benzene to producing thecompounds [4]a , [10,11]b and [20-22]b. Chemical modification of Poly(vinyl alcohol) were obtained by reaction of PVA withcompounds [4]a , [10,11]b and [20-22]b using the Dimethyl formamide to produce compounds [5]a ,[12,13]b and [23-25]b.The structure of the synthesized compounds were set by their analytical and spectral data such as , FTIR spectra , 1H-NMR. ,UV-Vis Spectroscopy and Elemental analysis (CHNS) . Finally study antibacterial activity screened via two types of bacteria.Anticancer activity also examined for all modifier polyvinyl alcohol.
رويدة سمير سعيد | Ruwaidah Samir Saeed | 6248