Sawsan M. Jabbar AL-Hasnawi* 1 , Salman A. AL-Jiboury2
الملخص الانجليزي
ackground: Immunological profile of LADA is not so clear, so detection of
cytokines is relevant to determine the extent and direction of immune responses.
Objective: the aim of the study is to identify role of pro-& anti-inflammatory
cytokines in diabetes progression and their relation with diabetes complications.
Methodology: level of the pro-inflammatory cytokines IL-6 and IFN-γ and the antiinflammatory cytokine IL-1 receptor antagonist (IL-1RA) were estimated in 90 subjects (34
known LADA cases, 36 D.M.2 cases & 20 healthy control participants), participating patients
were recruited from Diabetes outpatient clinic in AL-Hussein Teaching Hospital in Karbala
from June, 2013 through January, 2014. A clinical questioner containing personal data,
family history, type of diabetes, hemoglobin A1C( HA1C), body mass index (BMI), diabetes
duration& complications of diabetes was obtained from all patients. Statistical analysis done
by using the statistical package for social sciences (SPSS) software for windows, data of all
participants were entered and analyzed with appropriate statistical tests.
Results: levels of IL-6 & IL-1RA were significantly higher in D.M.2 and LADA cases than
controls & both are associated with complications in D.M.2 patients, in addition to positive
significant correlation between them. Regarding IFN-γ, it was significantly higher in LADA
group than D.M.2 group.
Discussion: Levels of IL-6 & IL-1RA are increased in complicated cases for both
LADA & D.M.2 groups & IFN-γ is more in LADA group.
Conclusion: up regulation of both pro- and anti-inflammatory mediators to
ameliorate inflammation in pathogenesis of diabetes.
Recommendation: Further studies on IL-1RA in diabetes are recommended to see
the useful effects of IL-1RA in preserving β-cell function and its therapeutic role in
both autoimmune & type 2 D.M.
سوسن محمد جبار الحسناوي | Sawsan M. Jabbar AL-Hasnawi | 3237