عنوان المقالة:Immunotoxic and genotoxic effects of arsenic and ameliorative potential of quercetin and probiotics in wister rats
عبير الأحمري | Abeer Alahmari | 5447
نوع النشر
مجلة علمية
المؤلفون بالعربي
د. عبير الأحمري أ.د. خديجة أدهم أ.د. أحمد الحميدي
الملخص العربي
Arsenic is a significant environmental public health concern. The aim of the present study is to investigate the possible immunotoxic and genotoxic roles of arsenic and the ameliorative effects of quercetin and probiotics as natural antioxidants. This study was performed on male adult Wistar rats divided into six groups: control, NaAsO2-treated, quercetintreated, probiotic–treated, NaAsO2 and quercetin-treated, and NaAsO2 and probiotics-treated. Blood samples collected from all animals were prepared for some oxidative, immunological and genetic aspects. Administration of arsenic decreased body and spleen weight, reduced serum antioxidant defense parameters and DNA content, increased liver, kidney, and brain weights, plasma malondialdehyde (MDA), myeloperoxidase (MPO), and serum cytokines (IL-1β, IL-6, TNF-α and IFN-γ). Adding quercetin to arsenic was effective in restoring the altered values of cytokines (IL-1β and IL-6), MPO, MDA, catalase (CAT) and reduced glutathione (GSH) induced by arsenic, whereas the presence of probiotics was effective in reducing genotoxicity and improving the changes of cytokines (TNF-α and IFN-γ) and superoxide dismutase (SOD). Quercetin and probiotics are excellent antioxidant therapies, through their ability to suppress reactive oxygen species ROS production, which may contribute to arsenic toxicity.
تاريخ النشر
01/08/2017
الناشر
American journal of life sciences
رقم المجلد
رقم العدد
ISSN/ISBN
2328-5737
رابط DOI
10.11648/j.ajls.20170504.13
رابط الملف
تحميل (190 مرات التحميل)
رابط خارجي
http://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20170504.13.pdf
الكلمات المفتاحية
Arsenic, Quercetin, Probiotics, Oxidative Stress, Lipid Peroxidation, Inflammation
رجوع