ABSTRACT
Background
As cardiovascular disease is the leading cause of mortality in type 2 diabetes mellitus (T2DM). Adiponectin
have substantial anti-inflammatory properties and to be a major modulator of insulin resistance and dyslipidemia.
Higher levels of adiponectin are associated with a reduced risk for cardiovascular diseases among diabetic patients.
Objective
To study the adiponectin levels in type 2 diabetic with and without cardiovascular diseases (CVD) and to
establish a relationship of adiponectin levels with cardiovascular complications of in T2DM patients.
Patients and Method
This cross-sectional/analytical study which included 573 individuals, 373 patients with T2DM
(220 of whom had both T2DM and CVD) and 200 healthy control. Serum adiponectin levels were analyzed by ELISA.
Results
The results revealed significant difference in serum adiponectin levels between patients had T2DM with CVD
and T2DM without CVD (6.90± 2.35 vs. 5.46± 2.25, P = 0.000) and between patients with T2DM and control
(6.90± 2.35 vs. 8.78± 2.92, P = 0.000). T2DM females and males with CVD revealed significantly low serum adiponectin
levels (5.91± 2.39, 5.10± 2.06) as compared to T2DM without CVD (7.40± 2.49, 6.31± 2.04), respectively. Logistic
regression analysis showed a higher cardiovascular risk (OR=1.73, 95% CI: 1.42-2.11, P=0.000) in T2DM individuals
when adiponectin levels were decreased.
Conclusion
Serum adiponectin levels are significantly reduced in T2DM with CVD as compared to
تاريخ النشر
31/12/2016
الناشر
International Journal of Diabetes & Research (TJPRC:IJDR)
د. حامد جدوع عباس | Dr. hamed Jaddoa Abbas | 14916